Q: Check engine light rough then goes away code cylinder 2 misfire changed plugs wires and cylinder 2 coil driving me nuts

The only things left to check is compression and the condition of the injector if you have changed the plug, wire, and coil. I would go with having the injectors cleaned. It is more likely that you have a clogged injector versus an internal cylinder problem causing low compression.

Clean the injectors by using a professional cleaning machine. Afterwards, clear the codes and use fuel tank injector cleaner to help keep the injectors clean. If you need some assistance with this, contact a certified technician who will be able to diagnose your Check Engine Light firsthand and perform the necessary repairs to your car.